Why do they work? All three are able to replenish some of what skin loses with time: collagen. Wrinkles form as collagen breaks down, which signals the cells that secrete it to stop doing so.
Treatments abound for crow's feet and fine lines, but there's plenty of confusion about what works and what's hogwash. Now comes some clarity.
Over the past decade, University of Michigan researchers have focused on the mechanisms behind aging skin and have emerged with a better understanding of how best to tame the process—without Botox or plastic surgery. After analyzing several dozen of their studies, the team reported last month that three treatments definitely rejuvenate skin: topical retinoic acid, carbon dioxide laser resurfacing, and injections of cross-linked hyaluronic acid. "These three, as far as I'm concerned, are the ones where the evidence is quite solid," says senior author John Voorhees, chair of the department of dermatology at the University of Michigan's medical school (who has no financial ties to the manufacturers of the treatments studied).
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